In this study, a detailed numerical simulation is carried out to investigate the transverse optical trapping in a water-filled microstructured hollow-core photonic crystal fiber (HC-PCF). Using the FDTD method and Maxwell’s stress tensor, the forces acting on the sphere placed at the centre core of HC-PCF is computed. The nature of the force at relative positions of the sphere is also studied. The obtained results indicate that these proposed concepts have significant potential for developing novel optical manipulation and trapping concepts inside such HC-PCF.