We have designed and developed a novel hand-held probe integrating a miniaturized charge-coupled device (CCD) video camera, light emitting diode (LED) light source and near infrared light source with specifications to capture the irido-corneal angle images and posterior segment images (Figure 1). The field of view for the camera was set at 140° for the irido-corneal angle. This dual mode probe was tested in a preclinical setting for imaging the angle and fundus in rabbits and non-human primates (NHP).